HELPING THE OTHERS REALIZE THE ADVANTAGES OF PKRRATING

The interfacial residues are remarkably conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a design where activating RNA serves as being a scaffold to bind numerous PKR monomers, expanding

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